The drug and homeless charity said that such centres are currently operating in more than 100 cities around the world.
"They are proven to create safer communities for all by reducing public drug use and drug litter, helping people into treatment, and most importantly, saving lives," it said.
Merchants Quay secured a licence to run the facility, but Dublin City Council planners ruled their south city location at the Riverbank building was contrary to the city's development plan.
The appeal lodged this afternoon is understood to argue that it was inappropriate for the council to have asked for a policing plan as part of the planning application.
Source: John Kilraine, RTE News, 21st August 2019